Silver Diamine Fluoride Versus Fluoride Varnish for Arresting Early Childhood Caries: A 12-Month Randomized Controlled Trial in Chennai, India
Kavitha Subramanian, Arun Selvaraj, Deepa Krishnamoorthy, Joseph Varghese, Meera Balasubramanian
Volume 6, Issue 5Article JDSIR-0605-02
Background. Early childhood caries remains highly prevalent in India, and many affected children have limited access to restorative care. Silver diamine fluoride (SDF) and sodium fluoride varnish are both used to arrest cavitated lesions, but direct comparisons in Indian preschool populations are scarce. Methods. In this examiner-blinded, parallel-group randomized controlled trial, children aged 36–71 months with at least one active cavitated dentin lesion were recruited from 24 anganwadi centers and preschools in Chennai and allocated to 38% SDF applied every 6 months or 5% sodium fluoride varnish applied every 3 months. The primary outcome was lesion arrest at 12 months, assessed by visual-tactile examination and analyzed with generalized estimating equations to account for clustering within children. Results. A total of 222 children with 979 lesions were randomized, and 205 (92.3%) completed follow-up. At 12 months, 71.9% of lesions treated with SDF and 43.2% of those treated with varnish were arrested (adjusted odds ratio 3.24, 95% CI 2.31–4.55; p < 0.001). All lesions were arrested in 46.2% versus 18.8% of children, respectively. New lesion development did not differ between groups. Parental satisfaction with appearance was lower in the SDF group (68.3% vs 89.1%), and adverse events were mild and transient. Conclusions. Semiannual 38% SDF arrested substantially more cavitated lesions than quarterly fluoride varnish over 12 months. Its low cost and simplicity support its use in community programs for preschool children in India, provided that parents are counseled about permanent black staining.